Patricia Inácio, PhD, science writer —

A variation in the growth hormone receptor (GHR) gene, specifically the lack of a coding sequence called exon 3, does not seem to increase the risk for scoliosis in Prader-Willi syndrome (PWS) patients, a small study reports. Exon 3 in the GHR gene was previously shown to be associated with increased growth…

Adult patients with Prader-Willi syndrome (PWS) show a lack of physical activity and deficient amounts of calcium, vitamin D, and fiber, a small study reports. These results support interventions to reduce sedentary lifestyles and the introduction of supplements to combat dietary deficiencies in Prader-Willi patients. The study, “…

Insys Therapeutics’ Phase 2 trial to evaluate the safety and effectiveness of its cannabidiol (CBD) oral solution in pediatric patients with Prader-Willi syndrome (PWS) will soon begin recruiting participants. More information about the study and dates of enrollment will be announced on the clinical trial’s official webpage, found here (NCT02844933).

Soleno Therapeutics recently released an update on the company’s achievements during 2017 and plans for its investigational therapeutic for Prader-Willi syndrome (PWS), a condition currently without an approved therapy. One of the highlights for the next steps in PWS is the FDA’s agreement with Soleno’s for a Phase 3 clinical…

Rhythm Pharmaceuticals has acquired the rights to develop and commercialize RM-853, an investigational therapy currently in preclinical research for Prader-Willi syndrome (PWS). RM-853, formerly known as T-3525770, is a potent oral inhibitor of ghrelin o-acyltransferase (GOAT), the key enzyme involved in the body’s production of the active form of ghrelin,…

In people with Prader-Willi syndrome, the severity of aberrant behaviors declines with age, a phenomenon that starts at around age 30, according to Japanese researchers. Food-related behaviors, however, are maintained and don’t seem to change as patients grow older. The study, “Aberrant, autistic, and food-related behaviors…