Palatin Technologies plans to move two obesity-targeting drugs — experimental therapies designed to activate the melanocortin-4 receptor (MC4R) protein, which is involved in appetite and energy balance — into clinical testing in people with Prader-Willi syndrome (PWS) this year. Planned trials will also test the company’s candidates in…
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An ongoing, global clinical trial testing Aardvark Therapeutics’ ARD-101 for hyperphagia, or excessive hunger, in people with Prader-Willi syndrome (PWS) has lowered the minimum enrollment age in the U.S. to allow children as young as 7 to take part, according to a study update. The Phase 3…
Non-obese children with Prader-Willi syndrome (PWS) have imbalances in the blood levels of signaling molecules that facilitate communication between muscles, bones, and fat tissue, a single-center study from Poland suggests. According to the researchers, such imbalances “may impair muscle development and bone metabolism” in “normal-weight children” with the rare…
Adolescents and adults with Prader-Willi syndrome (PWS) in Australia are largely following national healthy eating guidelines, yet they still face high rates of obesity due to consuming significantly more than what’s recommended for the condition. According to a new study, while these patients are choosing the right types of…
Adults with Prader-Willi syndrome (PWS) need substantial support with daily activities, including personal care, social interactions, and problem solving, according to a study from Japan. The results suggest “that once adulthood is reached, daily living skills and adaptive functioning remain largely consistent over time,” the researchers wrote. “Early intervention…
Epigenome editing, a technique that alters the chemical switches that turn genes on or off, can reactivate genes from the mother that are usually silent in Prader-Willi syndrome (PWS), a study using stem cells has found. According to the researchers, these laboratory findings provide new evidence that epigenome editing may…
Probiotic supplementation may increase the gut abundance of beneficial bacteria of the Bifidobacterium genus and improve social interactions in people with Prader–Willi Syndrome (PWS), without causing gastrointestinal adverse events. These are the main findings of a review study that pooled data from appropriately controlled clinical trials testing supplements of…
The injectable therapy setmelanotide, being developed by Rhythm Pharmaceuticals for Prader-Willi syndrome (PWS), curbs hyperphagia, or uncontrollable hunger, and reduces body weight in children and adults with obesity due to PWS. Those are the early findings of an exploratory Phase 2 clinical trial, ongoing at a single U.S.
Working closely with caregivers and clinical experts, an international team of scientists has adapted an eye-tracking test to more objectively measure the intense, constant hunger — called hyperphagia — that affects people with Prader-Willi syndrome (PWS). “By integrating stakeholder insights, we enhanced feasibility, accessibility and data quality,” demonstrating “the…
Sodium-glucose cotransporter-2 inhibitors (SGLT2is), a class of type 2 diabetes medications, may help improve blood sugar levels and support kidney health markers in adults with Prader-Willi syndrome (PWS) and type 2 diabetes, according to a study in France. Despite these benefits, the treatment did not lead to significant weight…
Recent Posts
- I’m hopeful a new treatment will benefit my son with Prader-Willi syndrome
- Palatin to test 2 obesity-targeting drugs for PWS in clinical trials this year
- Still-recruiting ARD-101 trial for PWS lowers US enrollment age to 7
- For rare disease families, February is a month of both love and awareness
- Muscle, bone signaling imbalances found in non-obese PWS children
- Most PWS patients meet nutrient targets but struggle with calorie control
- Adults with PWS need lifelong support in daily activities, study finds
- Celebrating a milestone in life with Prader-Willi syndrome
- New technique ‘wakes up’ silent genes in Prader-Willi in lab testing
- Probiotics may boost beneficial gut bacteria in Prader-Willi syndrome