Targeting an enzyme called EHMT2 may help treat Prader-Willi syndrome (PWS) by reactivating the maternal PWS genes that are normally turned off, according to a new study. PWS is caused by the loss of certain genes in a region of the paternal chromosome 15 called the PWS locus.
News
Adults with Prader-Willi syndrome (PWS) caused by a genetic deletion have higher obesity rates and more severe obesity than those with PWS associated with other genetic abnormalities, a study found. “Given the higher risk of obesity observed in individuals with the deletion subtype, our results support the need for…
Hypogonadism, a condition in which the body produces few or no sex hormones, is common in girls and young women with Prader-Willi syndrome (PWS). But while hormone replacement therapy (HRT) is often prescribed, many patients stop using it because of bothersome side effects, a U.S. study found. “These findings…
An imbalance of fatty molecules in the blood, as assessed by the triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C), can accurately detect metabolic syndrome in children and adolescents with Prader-Willi syndrome (PWS), a study has shown. Metabolic syndrome is a cluster of health conditions, including abdominal obesity, high blood pressure,…
Aardvark Therapeutics plans to expand its ongoing Phase 3 clinical trial of ARD-101, an oral therapy for easing excessive hunger in Prader-Willi syndrome (PWS), to include patients younger than 13. The decision, supported by the PWS community, is based on historical data indicating that younger PWS patients are…
Relmada Therapeutics is working toward the launch, next year, of a Phase 2 clinical trial to test sepranolone — which the company believes will be a first-in-class treatment for easing compulsive behaviors — in people with Prader-Willi syndrome (PWS). Preparations include engaging U.S. Food and Drug Administration officials…
Early findings from a Phase 2 clinical trial testing Rhythm Pharmaceuticals’ setmelanotide in children and adults with obesity due to Prader-Willi syndrome (PWS) are expected this year. That’s according to an update from Rhythm, which announced in a company press release that it plans to “disclose preliminary…
A Phase 3 trial testing the ability of Aardvark Therapeutics’ oral treatment candidate ARD-101 to ease hyperphagia, or insatiable hunger, in people with Prader-Willi syndrome (PWS) is still seeking adolescent and adult participants in the U.S., with other sites planned globally. Called HERO (NCT06828861), the study is…
Nearly all children with Prader-Willi syndrome (PWS) are hospitalized during their first year of life, a study reports. Hospitalizations in early childhood are generally more common with PWS than Angleman syndrome, another rare genetic disorder, the study found. Mortality rates also were higher in PWS, and 6% of…
People with Prader-Willi Syndrome (PWS) experience worse depression, overall health, and life satisfaction compared with the general population, according to validated questionnaires completed by more than 500 parents. With older age, depression tended to increase, while global health and life satisfaction tended to decrease, the data showed. “The validated…
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