Diogo Pinto,  —

Soleno Therapeutics announced the awarding of a patent for diazoxide choline controlled-release (DCCR) tablets, the company’s investigational therapy for Prader-Willi syndrome (PWS) being evaluated in a new Phase 3 trial. The patent covers “pharmaceutical formulations of diazoxide and diazoxide choline” to treat patients with poor lean body mass and a lean…

Soleno Therapeutics recently received fast track status from the U.S. Food and Drug Administration for diazoxide choline controlled-release (DCCR), its investigational treatment for Prader-Willi syndrome (PWS). DCCR is an extended-release, salt formulation of diazoxide, taken as a once-daily tablet. Diazoxide is a potassium channel activator, capable of crossing…

Sleeping children with Prader-Willi syndrome (PWS) and severe obstruction of the upper airways — those between the nose and the larynx — go without sufficient breathing for longer periods when their apnea is worse, compared to children without the disease but with the same levels of obstruction, a study reports. The…

People with Prader-Willi syndrome (PWS) may have an increased risk for coronary artery disease (CAD), a Portuguese case study suggests. CAD is the most common type of heart disease. It is characterized by the narrowing and hardening of arteries that supply blood to the heart due to the buildup…

A 24-week exercise program showed encouraging results in controlling obesity and diabetes in a young man with Prader-Willi syndrome, according to a case study. The intensive exercises resulted in reduced body weight, fat mass, and mean blood glucose. And an increase in blood insulin levels allowed researchers to stop…

The prevalence of gastro-esophageal reflux disease (GORD), a condition also known as GERD, was found to be high among patients with Prader-Willi syndrome (PWS), a new study shows. Researchers also found a strong link between tooth wear, or loss of tooth substance, and the prevalence of GORD, as well…

Low serotonin levels in the brain are responsible for a greater prevalence of affective psychosis in patients with a type of Prader-Willi syndrome (PWS) known as maternal uniparental disomy PWS (mUPD PWS), according to a study. Serotonin, a molecule found in the brain, is often referred to as a “happiness…

Silent aspiration, a consequence of a swallowing dysfunction, was detected in infants with Prader-Willi syndrome (PWS) by fluorescent live video, a study found. The research was published in the journal Medicine (Baltimore) in a study titled, “Silent aspiration in infants with Prader-Willi syndrome identified by videofluoroscopic swallow study.”…

In France, infants with Prader-Willi syndrome (PWS) are being diagnosed and receiving care soon after birth. But improvements are still needed, including proper prenatal and neonatal diagnosis and care, a study found. The findings were published in the journal Orphanet Journal of Rare Diseases in a study titled, “…