Saniona is launching a Phase 2b clinical trial of Tesomet to evaluate its potential in lessening the uncontrollable hunger of people with Prader-Willi syndrome (PWS). “The initiation of this Phase 2b clinical trial of Tesomet in Prader-Willi syndrome follows our recent initiation of a Phase 2b clinical…
News
Two boys with Prader-Willi syndrome (PWS) developed respiratory failure — a condition in which the oxygen level in the blood becomes too low — after surgery to correct scoliosis (a sideways curvature of the spine), a report says. “Even after scoliosis surgery, ‘periodic’ monitoring of respiratory failure with an…
N-Acetylcysteine (NAC) may help to reduce skin-picking behavior in some people with Prader-Willi syndrome (PWS), but many patients do not benefit from NAC treatment, a new study found. “NAC should continue to be considered as a treatment option for skin picking in PWS as over a third of severely…
MRI brain scans of Prader-Willi syndrome (PWS) patients unexpectedly revealed nerve cells in the cerebellum of the brain activated by food cues that promote appetite, a study demonstrated. The findings suggest that the cerebellum may be a potential target for treating obesity in people with PWS. The study, “…
A class of medications called GLP-1 receptor agonists (GLP1-RA) may help reduce appetite and promote weight loss for people with Prader-Willi syndrome (PWS), according to a review paper. The paper’s authors called for clinical trials to test these medicines in people with PWS. Their paper, “The…
The activity of nine genes located outside the so-called PWS locus — a region containing genes in Prader-Willi syndrome (PWS) that are lost or have defects — is significantly altered in people with the disease, according to a study in lab-grown nerve cells derived from patients and healthy individuals.
A new study is looking for participants to assess the impact of a behavioral training program for caregivers of children with Prader-Willi syndrome (PWS). The training program, led by Kasey Bedard, PhD, at the Chicago School of Professional Psychology, will be conducted virtually by Zoom and Qualtrics, according to…
Excessive eating in Prader-Willi syndrome (PWS) increases the risk of mortality not only by making patients prone to obesity and its associated health problems, but also by raising the risk of accidents like choking, a new study indicates. “There are the longer-term problems that arise through obesity and the…
Subtle heart changes in people with Prader–Willi syndrome (PWS) may begin relatively early in adulthood, and being overweight may be related to these cardiovascular abnormalities, a small study reported. “We need to manage obesity and obesity-related disorders in order to prevent heart failure and ischemic heart disease [reduced blood…
Infants and toddlers with Prader-Willi syndrome (PWS) have significantly lower blood levels of insulin-like growth factor 1 or IGF-1 — indicative of growth hormone (GH) deficiency — than their healthy peers, a small study in Japan shows. This is the first study to conduct this type of comparative analysis…
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