The Gairdner Foundation recently announced the 2018 Canada Gairdner awardees for $100,000 prizes that recognize important research and biomedical discoveries. Among the five laureates are Davor Solter and Azim Surani for their discovery of parent-inherited genomic imprinting, a mechanism that regulates gene activity and can induce diseases such as Prader-Willi…
News
Caring for patients with Prader-Willi syndrome (PWS) has a significant effect on caregivers’ quality of life, and caregivers are in need of better support, a recent study found. Despite the positive effects that growth hormone therapy has had for patients with PWS, including improving their height, strength, and sense of well-being, those…
Silent aspiration, a consequence of a swallowing dysfunction, was detected in infants with Prader-Willi syndrome (PWS) by fluorescent live video, a study found. The research was published in the journal Medicine (Baltimore)Â in a study titled, “Silent aspiration in infants with Prader-Willi syndrome identified by videofluoroscopic swallow study.”…
Obesity and insulin resistance are significant risk factors for developing type 2 diabetes in patients with Prader-Willi syndrome (PWS), highlighting the importance of regular monitoring of glucose, or sugar, levels in these patients. Severe obesity in childhood, which may develop into type 2 diabetes, is a common feature in patients…
Only 40% of orchidopexies — a surgery to correct undescended testes — in patients with Prader-Willi syndrome (PWS) are successful, compared to a high rate of success in the general population, according to a new study. Cryptorchidism is the failure of one or both testes to descend from the…
Genetic sequencing and the speed with which it can help diagnose a child’s disease — in addition to revealing the genes that cause at least half of the 7,000 rare diseases currently known — was the focus of a discussion by three top New York geneticists. The Feb. 28 conference,…
Diazoxide helps reduce weight, body fat, and improve blood glucose levels and endurance capacity, in mice models of Prader-Willi syndrome (PWS), a study shows. The findings suggest that diazoxide targets cellular mechanisms that contribute to PWS development. In addition, the study provides further evidence demonstrating diazoxide’s potential to treat…
When it comes to rare diseases, one that definitely makes the list is spinal muscular atrophy with respiratory distress — SMARD,  for short. Hunter Pageau, a 12-year-old boy from North Haven, Connecticut, is one of only 80 people in the world known to have SMARD, a motor neuron disease…
In his 10 months on the job, Commissioner Scott Gottlieb of the U.S. Food and Drug Administration is earning praise for his efforts to make clinical trials for new therapies more flexible and responsive to the needs of rare disease patients. From cystic fibrosis to epidermolysis bullosa, the FDA…
In France, infants with Prader-Willi syndrome (PWS) are being diagnosed and receiving care soon after birth. But improvements are still needed, including proper prenatal and neonatal diagnosis and care, a study found. The findings were published in the journal Orphanet Journal of Rare Diseases in a study titled, “…
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