News

Cactus Extract Reduces Appetite in PWS Mouse Model, Study Reports

Treatment with an Indian cactus extract reduces appetite in a mouse model of Prader-Willi syndrome (PWS) by interfering with a serotonin receptor in the animal’s brain, a study reports. The study, “Caralluma fimbriata extract activity involves the 5‐HT2c receptor in PWS Snord116 deletion mouse model,” was published in the journal …

Millendo Starts Phase 2b/3 Study Evaluating Livoletide as PWS Treatment

Millendo Therapeutics has launched a Phase 2b/3 clinical trial investigating the safety and efficacy of livoletide (AZP-531) in patients with Prader-Willi syndrome (PWS), the company announced. The rare genetic disease is characterized by hyperphagia (excessive eating) and obesity, caused by abnormal hormonal levels. Livoletide is designed to reduce…

Zafgen Suspends Plan to Initiate ZGN-1258 Program as Treatment for PWS

Preclinical studies on the long-term impact of the investigational therapy ZGN-1258, being developed as a potential therapy for Prader-Willi syndrome (PWS), revealed alarming toxicity events and safety issues, Zafgen, the therapy’s developer, has announced. Based on these negative results, the company has changed its plans for ZGN-1258,…

ConSynance Therapeutics Will Participate in Prader-Willi Trial Consortium

ConSynance Therapeutics, a biotechnology company that has developed two new candidate medicines for Prader-Willi syndrome (PWS), announced that it has joined the PWS Clinical Trial Consortium. The PWS Clinical Trial Consortium was established in 2015 to accelerate clinical trials in PWS by promoting multidisciplinary, pre-competitive, and international collaboration among stakeholders…

Tesomet Safe for Teens with PWS; More Data Needed to Show Efficacy

Data from an ongoing Phase 2a clinical trial showed that Tesomet (tesofensine/metoprolol) is safe and well-tolerated by adolescents with Prader-Willi syndrome (PWS). Eight of the nine adolescents included in the trial have enrolled in an open-label extension (OE) study, where they will proceed with Tesomet treatment for an additional…