News

Potential PWS Therapy DCCR May Provide Safe, Long-lasting Benefits, Clinical Studies Show

Treatment candidate diazoxide chloride controlled release (DCCR) may cause fewer and milder side effects than approved medication Proglycem (diazoxide suspension) in treating low blood sugar in Prader-Willi syndrome patients, as well as providing consistent benefits, according to Soleno Therapeutics’ clinical studies. The findings showed that DCCR temporarily raises glucose (sugar)…

Soleno Granted Patent Covering Potential Oral Treatment, DCCR, Now in Phase 3 Study in Patients

Soleno Therapeutics announced the awarding of a patent for diazoxide choline controlled-release (DCCR) tablets, the company’s investigational therapy for Prader-Willi syndrome (PWS) being evaluated in a new Phase 3 trial. The patent covers “pharmaceutical formulations of diazoxide and diazoxide choline” to treat patients with poor lean body mass and a lean…

Prader-Willi Patients Can Present Autism-related Symptoms, Australian Study Reports

A recent study from Australia revealed that patients with Prader-Willi syndrome (PWS) and Angelman syndrome can present autism symptoms, although the symptoms differ between the two conditions. According to the researchers, the findings have implications for treatment and intervention. Both Prader-Willi and Angelman syndrome are neurodevelopmental disorders that are…

OvaScience Merging with Millendo to Focus on Treatments for Rare Endocrine Diseases, Including PWS

A merger between OvaScience and Millendo Therapeutics will focus on advancing Millendo’s pipeline of treatments for orphan endocrine diseases (diseases involving hormones), including Prader-Willi syndrome (PWS), according to a press release. The merged company will operate under the name Millendo Therapeutics. “We are excited about the opportunities created by…

Surgery Can Successfully Treat Obstructive Sleep Apnea, Malocclusion in PWS, Case Study Reports

Patients with Prader-Willi syndrome (PWS) who develop significant obstructive sleep apnea and malocclusion can be successfully treated using surgical methods, according to a case report. The case study, “Orthognathic Correction in Prader-Willi Syndrome: Occlusion and Sleep Restored,” was published in The Cleft Palate-Craniofacial Journal. Prader-Willi children…

FDA Grants Fast Track Status to Soleno’s Investigational Therapy DCCR for PWS

Soleno Therapeutics recently received fast track status from the U.S. Food and Drug Administration for diazoxide choline controlled-release (DCCR), its investigational treatment for Prader-Willi syndrome (PWS). DCCR is an extended-release, salt formulation of diazoxide, taken as a once-daily tablet. Diazoxide is a potassium channel activator, capable of crossing…