News

Soleno Granted Patent Covering Potential Oral Treatment, DCCR, Now in Phase 3 Study in Patients

Soleno Therapeutics announced the awarding of a patent for diazoxide choline controlled-release (DCCR) tablets, the company’s investigational therapy for Prader-Willi syndrome (PWS) being evaluated in a new Phase 3 trial. The patent covers “pharmaceutical formulations of diazoxide and diazoxide choline” to treat patients with poor lean body mass and a lean…

Prader-Willi Patients Can Present Autism-related Symptoms, Australian Study Reports

A recent study from Australia revealed that patients with Prader-Willi syndrome (PWS) and Angelman syndrome can present autism symptoms, although the symptoms differ between the two conditions. According to the researchers, the findings have implications for treatment and intervention. Both Prader-Willi and Angelman syndrome are neurodevelopmental disorders that are…

OvaScience Merging with Millendo to Focus on Treatments for Rare Endocrine Diseases, Including PWS

A merger between OvaScience and Millendo Therapeutics will focus on advancing Millendo’s pipeline of treatments for orphan endocrine diseases (diseases involving hormones), including Prader-Willi syndrome (PWS), according to a press release. The merged company will operate under the name Millendo Therapeutics. “We are excited about the opportunities created by…

Surgery Can Successfully Treat Obstructive Sleep Apnea, Malocclusion in PWS, Case Study Reports

Patients with Prader-Willi syndrome (PWS) who develop significant obstructive sleep apnea and malocclusion can be successfully treated using surgical methods, according to a case report. The case study, “Orthognathic Correction in Prader-Willi Syndrome: Occlusion and Sleep Restored,” was published in The Cleft Palate-Craniofacial Journal. Prader-Willi children…

FDA Grants Fast Track Status to Soleno’s Investigational Therapy DCCR for PWS

Soleno Therapeutics recently received fast track status from the U.S. Food and Drug Administration for diazoxide choline controlled-release (DCCR), its investigational treatment for Prader-Willi syndrome (PWS). DCCR is an extended-release, salt formulation of diazoxide, taken as a once-daily tablet. Diazoxide is a potassium channel activator, capable of crossing…

Inversago Raises $7M to Develop New Cannabinoid-1 Receptor Blockers

Inversago Pharma has raised $7 million to support the development of a new generation of cannabinoid-1 (CB1) receptor blockers for the treatment of Prader-Willi syndrome, type 1 diabetes, and other metabolic disorders. With the money, Inversago plans to advance its new compounds into clinical trials. CB1 inhibitors have…

PATH for PWS, a Prader-Willi Study, to Start Enrolling Patients in September

Zafgen biopharma and the nonprofit Foundation for Prader-Willi Research (FPWR) have launched “PATH for PWS,” a natural history study aimed at advancing the understanding of the medical history and medical events in patients with Prader-Willi syndrome (PWS). The non-interventional, observational study aims to document serious medical events experienced by Prader-Willi patients…